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James n-hexane neuropathy due to rubber cement sniffing. Muscle Nerve. Polyneuropathy due to n-hexane. Arch Intern Med. Toxic polyneuropathies after sniffing a glue thinner. J Neurol. An outbreak of N-hexane induced polyneuropathy among press proofing workers in Taipei. Am J Ind Med. J Occup Med.
N-hexane neuropathy in offset printers. Clough SR. Encyclopedia of Toxicology.
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Thirdth ed. Oxford: Academic; Accessed 19 Dec European Commission. Chang YC. An electrophysiological follow up of patients with n-hexane polyneuropathy. Br J Ind Med. Peripheral and central conduction in n-hexane polyneuropathy. Neurotoxic effects of n-hexane on the human central nervous system: evoked potential abnormalities in n-hexane polyneuropathy. Toxic polyneuropathy of shoe workers in Italy. A clinical, neurophysiological and follow-up study. Ital J Neurol Sci. Probing mechanisms of axonopathy. Part II: Protein targets of 2,5-hexanedione, the neurotoxic metabolite of the aliphatic solvent n-hexane.
Toxicol Sci. Accessed 15 Aug Biological exposure indices of pyrrole adducts in serum and urine for hazard assessment of n-hexane exposure. PLoS One. Alternative Biomarkers of n-Hexane exposure: Characterization of aminoderived pyrroles and thiol-pyrrole conjugates in urine of rats exposed to 2,5-Hexanedione. Toxicol Lett. Download references. This manuscript was edited by Wallace Academic Editing.
JHP interpreted the patient data, collected references, and was a major contributor in writing the manuscript. CYP analyzed and interpreted the sampling result. All authors read and approved the final manuscript. Written informed consent was obtained from the patient for publication of this case report and any accompanying images.
Toxicological profile of orally administered 1,6‐hexane diamine in the rat
A copy of the written consent is available for review by the Editor-in-Chief of this journal. This patient was referred to us for further investigation of the relationship between his disease and occupational exposure. Under his agreement, we reviewed his medical record. We were allowed to perform the workplace investigation by the patient and his company. We had concealed all personal information. Our investigation would not elevate risk to his health or be against his benefit in anyway.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Correspondence to Jo-Hui Pan. Reprints and Permissions. Search all BMC articles Search. Abstract Background n -Hexane is a well-known neurotoxicant.
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Conclusions Despite a typical clinical presentation, his exposure at workplace was appropriately investigated. Open Peer Review reports. Background n -Hexane, with a molecular formula of C 6 H 14 , is a colorless liquid with a disagreeable odor. Table 1 Electromyography data Full size table.
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Table 2 Nerve conduction velocity data Full size table. Full size image. Table 3 The sampling result of n -hexane concentration in the air in the mixing room Full size table. Conclusions In conclusion, we have obtained compelling evidence of exposure through workplace investigation. References 1.
Assessment of Occupational Exposure to N-hexane: A Study in Shoe Making Workshops
PubMed Google Scholar 2. Google Scholar 3. The major use for solvents containing n-Hexane is to extract vegetable oils from crops such as soybeans. These solvents are also used as cleaning agents in the printing, textile, furniture, and shoemaking industries. Certain kinds of special glues used in the roofing and shoe and leather industries also contain n-Hexane.
Several consumer products contain n -Hexane, such as gasoline, quick-drying glues used in various hobbies, and rubber cement. Fact sheet that answers the most frequently asked questions about a contaminant and its health effects. Succinctly characterizes the toxicologic and adverse health effects information for a hazardous substance. The MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse, non-cancer health effects over a specified duration of exposure.
The information in this MRL serves as a screening tool to help public health professionals decide where to look more closely to evaluate possible risk of adverse health effects from human exposure. Treat vomiting with antiemetics and IV fluids. Monitor mental status. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis.
Administer oxygen and assist ventilation as required.
Screening Assessment for the Challenge Hexane
Treat bronchospasm with inhaled beta2-agonist and oral or parenteral corticosteroids. If irritation, pain, swelling, lacrimation, or photophobia persist, perform a slit lamp exam. Early use of PEEP and mechanical ventilation may be needed. Call you local poison control center for recommendations about surfactant as therapy.
IDLH: ppm is considered immediately dangerous to life and health. He recovered following an extensive incision and debridement of the limb. Any supplied-air respirator. Substance reported to cause eye irritation or damage; may require eye protection.