Professor London has written widely on foundational issues in the ethics and design of research with human subjects. His work on the ethics of international research has helped to shape the debate about the requirements of justice, responsiveness to host community health needs, post-trial access, how to define the standard of care and how to use the concept of clinical equipoise in cross-national research. Professor London has articulated a non-paternalistic foundation for the ethical oversight of research involving human subjects.
With colleagues, he has written a series of papers articulating a model for understanding clinical translation that identifies key benchmarks for assessing the ethical and scientific merits of proposals to reform research practice. This work emphasizes the role of incentives in aligning the parochial interests of stakeholders with the social mission of producing valid, reliable, and relevant scientific information.
1. INTRODUCTION: RESEARCH IN EMERGENCY SITUATIONS
In addition to his work on practical ethical and policy issues, Professor London maintains an active research program on foundational ethical and methodological issues in theoretical and practical ethics. He has explored the value of dignity in Kantian moral frameworks and the challenges this concept poses for rational decision making, in both group and individual choice settings.
He has also written about methodological issues in practical ethics. Mellon Foundation. Before joining Carnegie Mellon in , he was a post-doctoral fellow at the University of Minnesota's Center for Bioethics and he received his Ph. The PDFs of these papers are intended for personal academic use only and should not be distributed in any way.
Bharucha, A. Ethical considerations in the conduct of electronic surveillance research. Alex John London Kestigian, A. London, A. Social value, clinical equipoise, and research in a public health emergency. London AJ and Kimmelman J. DOI: London AJ. American Journal of Bioethics 19 9 , Published online June 13, June , Alex John London Clara L.
Curriculum vitae. Selected Publications The PDFs of these papers are intended for personal academic use only and should not be distributed in any way. McGraw Hill, Ethics and AI Bharucha, A. Groundhog Day for Medical Artificial Intelligence. Regulating autonomous vehicles: A policy proposal. Algorithmic Bias in Autonomous Systems.
Regulating Autonomous Systems: Beyond Standards. The Hastings Center Report 40 4 The Hastings Center Report 33 5 : Alex John London , Lisa S. Parker, Jay D. Science 13 September Vol. Is the concept of clinical equipoise still relevant to research? BMJ ;j doi : Journal of Medical Ethics. Patient-Funded Trials: Opportunity or Liability? World Medical Journal 59 5 : Journal of Law, Medicine, and Ethics 40 4 Science 4 May Vol. WHO continues to stress risk of more flare-up. January 15, Accessed March 9, Sierra Leone has 2nd Ebola case after epidemic believed over.
Latest Ebola outbreak over in Liberia; West Africa is at zero, but new flare-ups are likely to occur. Molecular evidence of sexual transmission of Ebola virus. N Engl J Med. Ebola RNA persistence in semen of Ebola virus disease survivors — preliminary report. Epub October 14, Folayan MO, Brown B. Ebola and the limited effectiveness of travel restrictions. Disaster Med Public Health Prep. Ebola vaccine development plan: concerns and proposed measures. BMC Med Ethics. Evaluation of convalescent plasma for Ebola virus disease in Guinea.
Medecins Sans Frontieres. Preliminary results of the JIKI clinical trial to test the efficacy of favipiravir in reducing mortality in individuals infected by Ebola virus in Guinea. February 24, Accessed January 23, Ebola crisis: WHO slammed by Harvard-convened panel over slow response. November 23, Accessed January 27, Roland D. The Wall Street Journal. May 12, Ethical considerations for use of unregistered interventions for Ebola virus disease EVD.
Summary of the panel discussion. August 12, Presidential Commission for the Study of Bioethics Issues. December 9, The Ebola outbreak, fragile health systems, and quality as a cure. Emergence of Zaire Ebola virus disease in Guinea.
Advances in Bioethics | Emerald Insight
Rid A, Emanuel EJ. Why should high-income countries help combat Ebola? Fauci AS. Ebola — underscoring the global disparities in health care resources. Human Development Report. Abramowitz SA. How the Liberian health sector became a vector for Ebola. Hot Spots, Cultural Anthropology website. October 7, Schroven A. Ebola in Guinea: revealing the state of the state.
Abdullahi AA. Trends and challenges of traditional medicine in Africa. Anoko JN. Communication with rebellious communities during an outbreak of Ebola virus disease in Guinea: an anthropological approach. International decade for action: water for life to Folayan MO, Haire B. History, culture and social norms: implications for Ebola drug and vaccine clinical trials. Introducing health facility accreditation in Liberia. Glob Public Health. Amnesty International. Out of reach: the cost of maternal health in Sierra Leone. Ebola viral disease outbreak — West Africa, Morb Mortal Wkly Rep.
Trvobic P. I had to turn people away from an Ebola treatment centre. The Guardian. September 11, Sifferlin A. This is how Ebola patients are equipping their homes. October 9, Ebola and the ex-combatant community. Koch T. Ebola, quarantine, and the scale of ethics.
Epub October 9, Is there a case for quarantine? Selgelid MJ. Ethics and infectious disease. Ethical and legal challenges posed by severe acute respiratory syndrome: implications for the control of severe infectious disease threats. Boseley S. February 26, Presidential Commission for the study of Bioethics Issues.
Rothstein MA. The moral challenge of Ebola. Am J Public Health. CBS News. Ebola fear causes stigma against West Africans in U. October 31, Accessed January 1, McCarthy M. US nurse says she will fight Ebola quarantine. Ebola in West Africa at one year — from ignorance to fear to roadblocks. Nossiter A. A hospital from hell, in a city swamped by Ebola. The New York Times. October 1, Igonoh A. November 14, Accessed March 6, Polesky A, Bhatia G.
Ebola hemorrhagic fever in the era of bioterrorism. Semin Respir Infect. International Covenant on Civil and Political Rights. Clinical management of Ebola virus disease in the United States and Europe. Ebola virus disease in West Africa — the first 9 months of the epidemic and forward projections. How Ebola roared back. December 29, Accessed December 30, Two US Ebola nurses free of virus. October 25, Kinsman J. A time of fear: local, national, and international responses to a large Ebola outbreak in Uganda.
Global Health. Ebola virus outbreak in Western Africa and the ethical obligation to provide care.
Biomedical Ethics in Methodist Traditions
J Med Ethics. Epub September 9, Cass C. Anxiety rising in U. October 5, Response to importation of a case of Ebola virus disease: Ohio, October Ebola outbreak: are health care workers prepared, protected? October 14, Texas healthcare worker is diagnosed with Ebola. Gulland A. Spanish authorities investigate how nurse contracted Ebola. Frader J, Friedman Ross L. Bioethics Forum. November 7, Accessed January 26, Edenson P.
Bieubien J. Dreaming up a safer, cooler PPE for Ebola fighters. January 4, Respiratory protection for healthcare workers treating Ebola virus disease EVD : are facemasks sufficient to meet occupational health and safety obligations?
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Int J Nurs Stud. Randomised controlled trials for Ebola: practical and ethical issues. Selecting the right tool for the job. Am J Bioeth. Ebola vaccine — an urgent international priority. Ethical considerations of experimental interventions in the Ebola outbreak. Dawson L. Goodman JL. Joffe S. Evaluating novel therapies during the Ebola epidemic.
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Evaluating Ebola therapies — the case for RCTs. Cooper, Ben S, Panngum W, et al. Evaluating clinical trial designs for investigational treatments of Ebola virus disease. PLoS Med. Cohen J, Kupferschmidt K. Ebola vaccine trials raise ethical issues. Edwards SJ. Ethics of clinical science in a public health emergency: drug discovery at the bedside. Caplan AL. Morality in the time of Ebola. Ebola: what it teaches us about medical ethics. A response to Angus Dawson. Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial.
Models for humanitarian health care ethics. Public Health Ethics. Dawson AJ. Ebola: what it tells us about medical ethics. Consultation on potential Ebola therapies and vaccines. Geneva, Switzerland. September 4—5, Singer P. Famine, affluence and morality. Philos Public Aff. Caney S.
Taking DNA from the dead. Nat Rev Genet. Ebola virus disease: ethics and emergency medical response policy. Ethical issues in the export, storage, and reuse of human biological samples in biomedical research: perspectives of key stakeholders in Ghana and Kenya. Fidler DP. Negotiating equitable access to influenza vaccines: global health diplomacy and the controversies surrounding avian influenza H5N1 and pandemic influenza H1N1. Geneva, Switzerland: WHO; International Charter of principles for sharing bio-specimens and data. Eur J Hum Genet. Gibbs JL. Property insurance may mitigate Ebola-related losses.
November 3, Heyden EC. Ebola survivors fight prejudice. December 18, Black market therapies for Ebola management: a potential for future epidemics. Glob Health Action. Edin K, Shaefer HL. Blood plasma, sweat, and tears. The Atlantic. September 1, Holding the bull by the horns: ethical consideration in designing multiple clinical trials and research protocols in the context of a dangerous pathogen outbreak. Soc Sci Med. Epub November 30, Ebola response roadmap situation report.