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The Best-Laid Plans of Nonprofit Marketers

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The best laid plans of mice and women

Photo Gallery. Trailers and Videos. Crazy Credits. Alternate Versions. Rate This. A seemingly simple plan to steal money goes increasingly awry. Director: Mike Barker. Writer: Ted Griffin. From metacritic. Josh Brolin Movies I've Seen. Movies Actor Josh Brolin. Use the HTML below.

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    Election Comedy Drama Romance. Cruel Intentions Edit Cast Cast overview, first billed only: Alessandro Nivola Nick Reese Witherspoon Lissa Josh Brolin Bryce Gene Wolande Lawyer Jonathan McMurtry Vet Terrance Sweeney Diner Waitress Rocky Carroll Bad Ass Dude Kate Hendrickson Bar Waitress Owen Bush Tatyana Golovkina, then a postdoc in my lab, showed that transgenic mice expressing viral superantigens as endogenous genes were protected against infection. This is because superantigen-specific T cells are deleted during neonatal shaping of the immune repertoire, resulting in the loss of a reservoir of actively dividing, infection-competent cells.

    These studies showed the power of using genetically manipulated mice to study virus biology. However, while we know that there are endogenous retroviruses in all species, many of which play important roles in the biology of their hosts, it has not yet been demonstrated that these viruses directly protect against exogenous infection in humans, an area yet to be explored. Since that time, we have gone on to identify many other genes that determine susceptibility to infection, including those involved in immune responses and virus entry.

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    Through these studies, we have expanded our virus portfolio to include both human and mouse retroviruses as well as New World hemorrhagic fever arenaviruses, and we have gone into research areas I never thought I would be involved in, including drug discovery and recently even neurology. While my lab now uses a variety of approaches to identify the genes that confer resistance and susceptibility, we always end up in the mouse. The mouse has sometimes led us from our best-laid plans, but more often than not, it has led us to new, exciting avenues of exploration.

    National Center for Biotechnology Information , U. PLoS Pathog. Published online Apr Susan R. Glenn F. Rall, Editor. Author information Copyright and License information Disclaimer. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    The Best Laid Plans

    Open in a separate window. Image 1. Funding Statement The author received no specific funding for this study. Support Center Support Center. External link.